The worsening global obesity epidemic, particularly the increase in childhood obesity, has prompted research into the mechanisms of appetite regulation. Complex pathways modulate energy balance, involving appetite centres in the hypothalamus and brain stem, and hormonal signals of energy status released by the gut and by the periphery. Better understanding of appetite regulation improves understanding of the aetiology of obesity. Manipulation of this homoeostatic system offers potentially useful treatments for obesity.
- food intake
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Funding: MD is funded by a Wellcome Trust Clinical Research Training Fellowship
Competing interests: SRB is a Director of Thiakis, a company developing gut hormones as therapeutic agents, and also has shares in the company