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Arch Dis Child 91:183-187 doi:10.1136/adc.2005.073759
  • Review

The regulation of appetite

  1. M Druce,
  2. S R Bloom
  1. Department of Metabolic Medicine, Imperial College London, 6th Floor, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
  1. Correspondence to:
    Prof. S R Bloom
    Department of Metabolic Medicine, Imperial College London, 6th Floor, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; s.bloom{at}imperial.ac.uk
  • Accepted 14 October 2005

Abstract

The worsening global obesity epidemic, particularly the increase in childhood obesity, has prompted research into the mechanisms of appetite regulation. Complex pathways modulate energy balance, involving appetite centres in the hypothalamus and brain stem, and hormonal signals of energy status released by the gut and by the periphery. Better understanding of appetite regulation improves understanding of the aetiology of obesity. Manipulation of this homoeostatic system offers potentially useful treatments for obesity.

Footnotes

  • Funding: MD is funded by a Wellcome Trust Clinical Research Training Fellowship

  • Competing interests: SRB is a Director of Thiakis, a company developing gut hormones as therapeutic agents, and also has shares in the company