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Old world cutaneous leishmaniasis infection in children: a case series
  1. J Jones1,
  2. J Bowling1,
  3. J Watson1,
  4. F Vega-Lopez1,
  5. J White2,
  6. E Higgins2
  1. 1Department of Dermatology, The Middlesex Hospital and Hospital for Tropical Diseases, University College London Hospitals, NHS Trust, London, UK
  2. 2Department of Dermatology, King’s College Hospital, London, UK
  1. Correspondence to:
    Dr J M Jones
    Department of Dermatology, University College London, 100 Eton Place, Eton College Road, London NW3 2DT, UK; docjenjaol.com

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Leishmaniasis currently threatens 350 million people in 88 countries around the world. Ninety per cent of cutaneous leishmaniasis (CL) cases occur in Afghanistan, Brazil, Iran, Peru, Saudi Arabia, and Syria. An epidemic of cutaneous leishmaniasis is ongoing in Kabul, Afghanistan with an estimated 200 000 cases. Lesions can be very disfiguring, particularly on the face, which may have long term psychological and social consequences. Over the past 10 years endemic regions have been spreading further afield and there has been a large increase in the number of recorded cases.

Over the past five years, at the Hospital of Tropical Diseases in London, we have been involved in the diagnosis and treatment of six children with CL due to L tropica and three children with cutaneous leishmaniasis due to L major. In our patients species identification was made by polymerase chain reaction (PCR).

L tropica CL usually manifests as dry, small, self-healing lesions, mainly located on the face, which heal with permanent scarring, while lesions due to L major tend to present as single or multiple “wet” ulcers.

In leishmaniasis recidivans, also called lupoid leishmaniasis, brown-red or brown-yellow papules appear in or adjacent to an old lesion of CL. Two children in our series with L tropica infection presented with features of lupoid leishmaniasis (fig 3).

Figure 1

 (A) An ulcerated, nodular plaque with diffuse dermal infiltration involving the upper lip in an 8 year old girl from Pakistan (L tropica). (B) Ulcerated nodular plaques on the cheeks of a 3 year old boy from Turkey (L tropica). (C) An ulcerated plaque on the forehead of a 5 year old boy from Afghanistan (L tropica). (D) An ulcerated plaque above the lip of a 10 year old boy from Afghanistan (L tropica).

Figure 2

 (A) A 3 year old boy from Turkey following treatment with systemic sodium stibogluconate. (B) An 8 year old girl from Pakistan, following treatment with systemic sodium stibogluconate.

Figure 3

 (A) Lupoid leishmaniasis with scarring due to previous L tropica infection and the presence of red/brown papules at the periphery of the scar. (B) Lupoid leishmaniasis with scarring due to previous L tropica infection, and two red/brown nodules at the superior and inferior poles, of the scar on the left cheek of a 9 year old boy from Afghanistan

Figure 4

 Crusted plaque on the forearm of a young boy from Algeria (L major).

Three children with L tropica were treated in hospital with systemic sodium stibogluconate 20 mg/kg daily for 3–4 weeks. The remaining three children with CL due to L tropica received intralesional sodium stibogluconate. In addition, one of the children with lupoid leishmaniasis required surgical excision of two nodules.

The three children with L major disease were treated with oral itraconazole at a dose of 10 mg/kg daily for 6 weeks. In all children, treatment resulted in resolution of their lesions.

The diagnosis of CL infection has to be suspected in children presenting with chronic, nodular, or ulcerated facial lesions. Diagnosis should be confirmed with, Giemsa stained smears looking for amastigotes, histology looking for granulomas +/− amastigotes, culture in NNN medium to grow promastigotes, and PCR with Old World primers.

Sensitivity of direct microscopy is low and parasitological culture not always successful, whereas PCR is a highly sensitive and specific test which allows species identification. Pentavalent antimonials are an effective treatment in the majority of cases by L tropica and seem to have few side effects in children. Spontaneous resolution is common in cases with L major cutaneous leishmaniasis. With an increasing immigrant population from endemic regions to the UK, a higher frequency of these previously rarely seen cases is expected.

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Footnotes

  • Parental consent was obtained for publication of figures

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