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Acute paediatrics
The significance of elevated CSF lactate
  1. S L Chow1,
  2. Z J Rooney1,
  3. M A Cleary1,
  4. P T Clayton1,2,
  5. J V Leonard1,2
  1. 1Metabolic Unit, Great Ormond Street Hospital for Children, London, UK
  2. 2Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College London, London, UK
  1. Correspondence to:
    Professor James Leonard
    40A Bagley Wood Road, Kennington, Oxford, OX1 5LY, UK; j.leonardich.ucl.ac.uk

Abstract

The final diagnosis of 158 patients who had a cerebrospinal fluid (CSF) lactate concentration greater than 2 mmol/l was ascertained. The conditions included seizures, inflammatory changes, and proven metabolic disorders. For the diagnosis of congenital lactic acidoses, CSF lactate should ideally be measured in a seizure free patient after any acute illness.

  • CSF, cerebrospinal fluid
  • cerebral inflammation
  • cerebral ischaemia
  • congenital lactic acidosis
  • mitochondrial disorder
  • seizures

https://doi.org/10.1136/adc.2005.075317

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