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In a preterm infant, does blood transfusion increase the risk of necrotizing enterocolitis?
  1. J C Agwu,
  2. H Narchi
  1. Department of Paediatrics, Sandwell Healthcare NHS Trust, Hallam Street, West Bromich B71 4HJ, UK; sagwu22890@aol.com

    https://doi.org/10.1136/adc.2004.051532

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      An otherwise well 3 week old infant born at 28 weeks gestation has a haemoglobin level of 68 g/l and is prescribed a blood transfusion. The departmental protocol states feeds should be withheld during the transfusion to decrease the risk of development of necrotising enterocolitis (NEC). What is the evidence that blood transfusion increases the risk of NEC?

      Structured clinical question

      In a preterm infant [patient] does blood transfusion [intervention] increase the risk of NEC [outcome]?

      Search strategy and outcome

      Search words: “transfusion” AND “necrotizing enterocolitis” (excluding exchange transfusion).

      Secondary sources—Cochrane Library (Issue 3, 2003): no relevant systematic review.

      Pub Med (1975–2003). Limits: newborn. Search outcome: 85 articles, of which two …

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      Footnotes

      • Bob Phillips