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Fertility preservation in adolescent males with cancer in the United Kingdom: a survey of practice
  1. A W Glaser1,
  2. L Phelan1,
  3. M Crawshaw2,
  4. S Jagdev1,
  5. J Hale3
  1. 1Yorkshire Regional Centre for Paediatric Oncology and Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  2. 2Department of Social Policy and Social Work, University of York, UK
  3. 3Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
  1. Correspondence to:
    Dr A Glaser
    Consultant Paediatric and Adolescent Oncologist, Children’s Day Hospital, St James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK; adam.glaserleedsth.nhs.uk

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Fatherhood is an important issue to young men surviving cancer as fertility may be impaired by treatment.1 A number of strategies to preserve fertility are available to adolescent males. Wide variation in practice for adolescent male fertility preservation has previously been shown in North America.2 No defining data for the UK are available. In the UK, these activities are regulated by the Human Fertilisation and Embryology Authority (HFEA).3

PARTICIPANTS, METHODS AND RESULTS

A national postal survey of all 22 regional paediatric oncology centres (POCs) and all HFEA licensed assisted conception units (ACUs) actively involved in clinical practice in the UK was performed. The aim was to document common practices and areas of variance, and to identify concerns of multidisciplinary healthcare professionals.

Twenty POCs (90%) responded; all offered access to storage facilities for sperm and/or testicular tissue for adolescents under the age of 18 years. Sixty five ACUs (62%) responded, of whom 23 currently offered storage facilities for this group. Only six ACUs named by POCs as their referral unit responded, thereby preventing detailed correlation between paired centres (the other 17 centres may have offered gamete storage to adolescents with either non-malignant conditions requiring chemotherapy or those being treated in adult cancer units). Table 1 shows available collection techniques together with the number of centres actually utilising them. All four units storing tissue from epididymal aspiration or testicular biopsy were doing this as part of a clinical programme with no parallel research programme.

Table 1

 Available and utilised strategies for gamete collection

Fourteen POCs (70%) offered fertility preservation to individuals who had begun but not completed sexual development. No centres offered this service prior to the onset of sexual development. Nineteen (75%) offered it to individuals with prior exposure to chemotherapy.

Fifteen POCs (75%) and seventeen ACUs (74%) required individuals to be Gillick competent for sperm banking, while seven POCs (35%) and 10 ACUs (43%) required this for testicular biopsy or epididymal aspiration.4 Written information regarding fertility preservation specifically for males under 18 years of age with cancer was reported to be given by 11 POCs (55%) and two respondent ACUs (9%). Consent was obtained by a wide range of professional groups, including reproductive medicine physicians, paediatric oncologists, andrologists, and nurses.

Psychosocial support is a statutory requirement for ACUs. It was available for patients in 15 ACUs (65%) and in 12 (52%) for their partners or parents. Twelve ACUs (52%) felt their staff had adequate training, experience, and qualifications to offer this service.

Written guidelines regarding fertility preservation were available in eight POCs (40%). Eight of the remaining centres (75%) had discussed but not implemented guidelines over the previous three years. Twenty (87%) of the ACUs working in this field indicated they would welcome national guidelines.

COMMENT

Variation in available services for the fertility preservation of adolescent males exists across the UK. The forthcoming detailed audit of these activities by the United Kingdom Children’s Cancer Study Group and recommendations produced by the British Fertility Society will hopefully clarify some of these issues.5 However, this study suggests that statutory requirements are not being met by all centres:1 counselling should be available to all and consent is required from all individuals, and not proxies, whenever mature gametes are stored. Thus, those under 16 years of age in Scotland and 18 years in England and Wales must be Gillick competent to undergo this procedure, a condition not being met by 25% of ACUs for semen donation from adolescents. Interestingly, contrary to medical and parental opinion, adolescents have previously been found to welcome the opportunity to address fertility preservation at a time when cancer chemotherapy is being contemplated.6

It is recognised that any child with testicular volume of greater than 4 ml (Tanner stage 2 or above) should be considered as potentially harbouring mature gametes.5 Further legislative changes have been recommended, by the McLean Review and British Fertility Society, which would enable mature gametes to be obtained from, and stored for, “non-Gillick competent” gamete providers as long as it is in their best interests.7 However, results of this survey indicate that while the consent provisions of the Human Fertilisation and Embryology Act 1990 remain, an urgent programme of education for health care professionals is required.

Acknowledgments

The authors acknowledge the support and advice of the Project Advisory Group. Dr Gill Levitt (UKCCSG Late-effects Group Chair) and Dr Hamish Wallace reviewed the draft manuscript.

REFERENCES

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Footnotes

  • Funding: NHS Executive (Northern and Yorkshire) RRCC240SG

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