Home based therapy for severe malnutrition with ready-to-use food
- 1Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
- 2College of Medicine, University of Malawi
- 3Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Finland
- 4Institut de Recherche pour le Développement, Paris, France
- Correspondence to:
Assistant Professor M Manary
Department of Pediatrics, St Louis Children’s Hospital, One Children’s Place, St Louis, MO 63110, USA;
- Accepted 29 September 2003
Background: The standard treatment of severe malnutrition in Malawi often utilises prolonged inpatient care, and after discharge results in high rates of relapse.
Aims: To test the hypothesis that the recovery rate, defined as catch-up growth such that weight-for-height z score >0 (WHZ, based on initial height) for ready-to-use food (RTUF) is greater than two other home based dietary regimens in the treatment of malnutrition.
Methods: HIV negative children >1 year old discharged from the nutrition unit in Blantyre, Malawi were systematically allocated to one of three dietary regimens: RTUF, RTUF supplement, or blended maize/soy flour. RTUF and maize/soy flour provided 730 kJ/kg/day, while the RTUF supplement provided a fixed amount of energy, 2100 kJ/day. Children were followed fortnightly. Children completed the study when they reached WHZ >0, relapsed, or died. Outcomes were compared using a time-event model.
Results: A total of 282 children were enrolled. Children receiving RTUF were more likely to reach WHZ >0 than those receiving RTUF supplement or maize/soy flour (95% v 78%, RR 1.2, 95% CI 1.1 to 1.3). The average weight gain was 5.2 g/kg/day in the RTUF group compared to 3.1 g/kg/day for the maize/soy and RTUF supplement groups. Six months later, 96% of all children that reached WHZ >0 were not wasted.
Conclusions: Home based therapy of malnutrition with RTUF was successful; further operational work is needed to implement this promising therapy.
- MUAC, mid-upper arm circumference
- NRU, nutritional rehabilitation unit
- RTUF, ready-to-use food
- WHZ, weight-for-height z score