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Community child health, public health, and epidemiology
α1 Antitrypsin and the prevalence and severity of asthma
  1. O S von Ehrenstein1,
  2. E M Maier1,
  3. S K Weiland2,
  4. D Carr1,
  5. T Hirsch3,
  6. T Nicolai1,
  7. A A Roscher1,
  8. E von Mutius1
  1. 1University Children’s Hospital, Munich, Germany
  2. 2University of Münster, Institute of Epidemiology and Social Medicine, Germany
  3. 3Children’s Hospital, Technical University, Dresden, Germany
  1. Correspondence to:
    Dr E von Mutius
    Dr von Haunersche Kinderklinik, Lindwurmstr. 4, D-80337 München, Germany; Erika.Von.Mutiusmed.uni-muenchen.de

Abstract

In a random sample of children (aged 9–11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the α1 antitrypsin (α1-AT) Pi genotypes MS or MZ, or low α1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of α1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.

  • childhood asthma
  • α1-antitrypsin heterozygosity
  • epidemiology

https://doi.org/10.1136/adc.2002.023614

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      Archives of Disease in Childhood 2004; 89 201-201 Published Online First: 20 Feb 2004.