Neonatal respiratory morbidity at term and the risk of childhood asthma
- 1Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
- 2Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
- 3Department of Public Health, Greater Glasgow NHS Board, Glasgow, UK
- 4Department of Fetal Medicine, The Queen Mother’s Hospital, Glasgow, G3 8SH, UK
- 5Information and Statistics Division, Common Services Agency, Edinburgh, UK
- Correspondence to:
Professor G C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Robinson Way, Cambridge, CB2 2QQ, UK;
- Received 26 February 2004
- Accepted 9 March 2004
Objective: To determine whether neonatal respiratory morbidity at term is associated with an increased risk of later asthma and whether this may explain previously described associations between caesarean delivery and asthma.
Design: Retrospective cohort study using Scottish Morbidity Record (SMR) data of maternity (SMR02), neonatal (SMR11), and acute hospital (SMR01) discharges.
Participants: All singleton births at term between 1992–1995 in 23 Scottish maternity hospitals.
Main outcome measures: Hospital admission with a diagnosis of asthma in the principal position between 1992 and 2000.
Results: Children who had a diagnosis of transient tachypnoea of the newborn or respiratory distress syndrome were at increased risk of being admitted to hospital with a diagnosis of asthma (hazard ratio (HR) 1.7, 95% confidence interval (95% CI) 1.4 to 2.2, p<0.001). This association was observed both among children delivered vaginally (HR 1.5, 95% CI 1.1 to 2.0, p = 0.007) and among those delivered by caesarean section (HR 2.2, 95% CI 1.6 to 3.0, p<0.001). In the absence of neonatal respiratory morbidity, delivery by caesarean section was weakly associated with the risk of asthma in childhood (HR 1.1, 95% CI 1.0 to 1.2, p = 0.004). The strengths of the associations were similar whether the caesarean delivery was planned or emergency and were not significantly altered by adjustment for maternal, obstetric, and other neonatal characteristics.
Conclusions: Neonatal respiratory morbidity at term is associated with an increased risk of asthma in childhood which may explain previously described associations between caesarean delivery and later asthma.
- HR, hazard ratio
- ICD, International Classification of Disease
- IQR, inter-quartile range
- RDS, respiratory distress syndrome
- SMR, Scottish Morbidity Record
- TTN, transient tachypnoea of the newborn