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Letter
Miconazole and clobazam; a useful interaction in Dravet’s syndrome?
  1. J Goldsmith1,
  2. C McKnight2,
  3. S Dickson3,
  4. M Heenan3,
  5. R Berezowski3
  1. 1Wanganui Hospital, Private Bag 3003, Wanganui, New Zealand; johngold@clear.net.nz
  2. 2Wanganui, New Zealand (mother of the patient)
  3. 3Institute of Environmental Science & Research Limited, PO Box 50-348, Porirua, New Zealand

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      Chiron and the STICLO study group report a dramatic improvement in seizure control in children with severe myoclonic epilepsy in infancy or Dravet’s syndrome (DS) when treated with valproate, clobazam, and stiripentol.1 Stiripentol inhibits the metabolism of clobazam and its metabolite norclobazam by P450 cytochromes.

      SM, 9 year old girl with DS and severe developmental delay had poor seizure control and frequent status epilepticus despite various combinations of antiepileptic medicines, most recently lamotrigine 35 mg/kg/day and nitrazepam 0.8 mg/kg/day. Careful seizure …

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