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Should nifedipine be used to counter low blood sugar levels in children with persistent hyperinsulinaemic hypoglycaemia?
  1. Dominik Müller1,
  2. Miriam Zimmering2,
  3. Charles Christoph Roehr3
  1. 1Department of Pediatric Nephrology, Charité, Humboldt University, Berlin, Germany
  2. 2Department of Pediatric Nephrology, Charité, Humboldt University, Berlin, Germany
  3. 3Department of Neonatology, Charité Campus Mitte, Humboldt University, Berlin, Germany; christoph.roehr@charite.de

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      A 5 year old boy, suffering from hyperinsulinaemic hypoglycaemia since infancy and arterial hypertension secondary to polycystic kidney disease, was given nifedipine (0.3 mg/kg three times a day) to treat his high blood pressure. Normotension was restored and his blood sugar levels normalised. We wondered whether nifedipine could be used safely as long term treatment to counter hypoglycaemia in persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI)?

      Structured clinical question

      In a child with persistent hyperinsulinaemic hypoglycaemia of infancy [patient], can nifedipine [intervention] safely be given to treat hypoglycaemia [outcome]?

      Search strategy and outcome

      Search terms: “persistent hyperinsulinemic hypoglycaemia of infancy” and “hyperinsulinism” and “nifedipine” and “safety” and “calcium antagonist”.

      Cochrane Library (nifedipine or persistent hyperinsulinemic hypoglycaemia of infancy): no relevant study found. PubMed (limits: language English; age 0–18 years): one practice guideline,1 six case reports or patient series of PHHI treated with nifedipine,2–7 one report on …

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      Footnotes

      • Bob Phillips