Arch Dis Child 88:582-583 doi:10.1136/adc.88.7.582
  • Community child health, public health, and epidemiology

Long term effects of long chain polyunsaturated fats in hyperphenylalaninemic children

  1. C Agostoni1,
  2. E Verduci1,
  3. N Massetto2,
  4. L Fiori1,
  5. G Radaelli3,
  6. E Riva1,
  7. M Giovannini1
  1. 1Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy
  2. 2Department of Neurology, San Paolo Hospital
  3. 3Unit of Medical Statistics, San Paolo Hospital
  1. Correspondence to:
    Dr C Agostoni, Department of Pediatrics, San Paolo Hospital, 8 Via A. di Rudinì, I-20142 Milano, Italy; e-mail:
  • Accepted 3 November 2002


Blood fatty acid status and visual function of 20 treated hyperphenylalaninemic (HPA) children, randomly allocated into two groups to receive supplementation of either long chain polyunsaturated fatty acids (LCPUFA), including docosahexaenoic acid (DHA), or placebo for 12 months, have been investigated three years after the end of the treatment. Although in the LCPUFA group blood DHA levels and P100 wave latency improved at the end of supplementation, they had returned to baseline after three years.