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Pantoea agglomerans as a cause of septic arthritis after palm tree thorn injury; case report and literature review
  1. A Kratz1,
  2. D Greenberg2,
  3. Y Barki3,
  4. E Cohen4,
  5. M Lifshitz1
  1. 1Pediatrics Department D, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel
  2. 2Pediatric Infectious Disease Unit, Soroka University Medical Center
  3. 3Department of Radiology, the Ultrasound Unit, Soroka University Medical Center
  4. 4Department of Orthopedic Surgery, Soroka University Medical Center
  1. Correspondence to:
    Dr M Lifshitz, Pediatrics Department D, Soroka University Medical Center, PO Box 151, Beer-Sheba 84101, Israel;
    matyl{at}bgumail.bgu.ac.il

Abstract

We report the case of a 14 year old healthy boy, who was admitted six weeks after being injured by a palm tree thorn, with limping caused by pain and swelling in his right knee. An ultrasound examination revealed a foreign body in the posterior lateral aspect of the right knee. Pantoea agglomerans was identified in the synovial fluid. The patient underwent two arthrotomies and was treated with amoxicillin-clavulanate intravenously for three weeks. The postoperative course was uneventful, and joint function returned to normal.

A review of the literature between 1953 and 2002 revealed that bacterial growth after plant thorn injuries is reported infrequently. Yet when reported, Pantoea agglomearns is the most common organism found. Therefore, it must be considered and suspected in “aseptic” cases of arthritis, when there is a history of a plant thorn injury. We also emphasise the efficacy of ultrasound examination in these cases to identify the presence and location of a plant thorn.

  • Pantoea agglomerans
  • septic arthritis
  • plant
  • thorn

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A 14 year old healthy boy was admitted to the hospital with pain and swelling in his right knee. He reported that six weeks prior to admission he had tripped over a palm tree branch and a thorn had penetrated his right knee. At that time, mild swelling and pain had been observed in the area of his right knee, and he had been treated with oral amoxicillin-clavulanate (2 g/day) for 10 days. The swelling and pain resolved. Two days prior to admission, notable swelling and pain in his right knee was observed.

Physical examination on admission showed an afebrile patient in good condition. His right knee was warm, swollen, and tender. Considerable limitation of active and passive range of motion was noted. Blood leucocyte count was 8.15 × 106 cells/l with 74% neutrophils. Erythrocyte sedimentation rate was 115 mm/h. Radiographs of the knee showed only soft tissue swelling, and no foreign body was detected. An arthrocentesis yielded 80 ml of purulent fluid. Direct microscopic examination of the fluid revealed many leucocytes, but no bacteria. Laboratory examination of the joint fluid showed 92.8 × 106 leucocytes/l with 86% neutrophils. A radioisotope scan with technetium was performed, showing an increased uptake in soft tissue and in the articular space.

The case was diagnosed as septic arthritis, and empiric treatment with cloxacillin (2 g four times daily) intravenously was started. Growth of a Gram negative bacillus from the joint fluid was detected in the BACTEC Peds Plus F broth (Becton Dickinson, Meylan, France). The final identification of the bacteria by the Vitec system (bioMerieux, Hazelwood, MO) was Pantoea agglomerans. Based on the strain susceptibility, treatment was replaced by intravenous amoxicillin-clavulanate (3 g/day). Ultrasound examination of the knee showed fluid accumulated in the suprapatellar bursa, and a foreign body, approximately 8 mm long, in the posterior lateral aspect of the knee (fig 1).

Figure 1

A foreign body with approximate length of 8 mm (the date palm thorn) is seen in the posterior lateral aspect of the knee (between the black arrows).

The patient underwent an arthrotomy with joint irrigation, but no foreign body was found. Intravenous antibiotic therapy was continued; the patient remained afebrile, and the swelling decreased, but there was still a limited range of movement and no further clinical improvement. The erythrocyte sedimentation rate was still raised (100 mm/h). A second ultrasound examination showed fragments of the foreign body lateral to the former location. The patient underwent a second arthrotomy. A small pouch, containing pus and surrounded by tiny fragments of thorn, was found and removed. Postoperative ultrasound examination revealed no trace of foreign body remnants. The patient remained hospitalised for one further week. The postoperative course, including a four week follow up examination, was uneventful, and joint functioning returned to normal.

DISCUSSION

Arthritis caused by plant thorn penetration is a well known medical condition, especially among children.1–9 It has been described following injuries from thorns of several kinds of plants, including palm, yucca, hawthorn, bougainvillea, sentry plant, blackthorn, cactus. and rose thorn.1–9

The thorn of the date palm (Phoenix dactylifera; fig 2) is particularly dangerous as the tip (distal 0.5–1.5 cm; fig 3) dries out much faster than the remaining parts of the thorn, and therefore is prone to break off within the joint, disintegrating into very small particles.

Figure 2

The date palm (Phoenix dactylifera).

Figure 3

The thorn tip of the date palm (0.5–1.5 cm) (black arrows).

Historically, failure to discover an organism in the joint fluid after a plant thorn injury led to the hypothesis, first published in 1953,2 that the arthritis or synovitis after these injuries was the result of an allergic reaction, mostly caused by plant toxins, and hence was aseptic. A review of numerous reports of plant thorn arthritis and synovitis published between 1953 and 2002 revealed that reports of organisms found in cultures of joint fluid were very rare1,3–9 but when reported, Pantoea agglomerans was the most common organism (5 of 11 cases; table 1).

Table 1

Summary of all cases with positive cultures

Pantoea agglomerans (formerly named Enterobacter agglomerans, and earlier referred to as Erwinia herbicola) is a member of the Enterobacteriaceae. This Gram negative bacterium can be found in human and animal faeces and in plants. The earliest reports of human infections caused by this organism were published in the early 1970s.10,11

The first case of arthritis caused by Pantoea agglomerans was reported in 1978, after a wooden splinter had penetrated a patient’s knee.5 A similar case of knee arthritis after a blackthorn injury was reported seven years later.6 In 1991, Olenginski et al reported a series of seven patients suffering from plant thorn synovitis, of which only one case showed a positive joint fluid culture for Pantoea agglomerans.7 De Champs et al reported two cases of septic monoarthritis caused by Pantoea agglomerans.8

In all cases described, as well as in our case, the foreign body was not detected by x ray examination. In our patient the existence and location of a foreign body was confirmed by ultrasound examination. Most authors note the delay in establishing a correct diagnosis (up to nine months),8 since the inflammation often develops long after the thorn injury has occurred. On the basis of a review of the literature, the recommended method to achieve complete recovery is arthrotomy and removal of the thorn.1–8

Pantoea agglomerans has an important role in the pathogenesis of plant thorn arthritis after a thorn injury. It seems that many cases of “aseptic” arthritis after a plant thorn injury are actually Pantoea agglomerans septic arthritis. Inappropriate growth media and inaccurate identification methods could be the reason for negative results in culture identification. Therefore, the use of methods capable of recognising Pantoea agglomerans is recommended when a history of any thorn injury exists. An ultrasound or magnetic resonance imaging examination should be used to identify and locate suspected foreign bodies.12 Removal of the foreign bodies by arthrotomy, combined with antibiotic therapy, seems to be the most effective treatment to achieve complete recovery.

REFERENCES

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