Article Text
Acute paediatrics
Acute encephalopathy with parvovirus B19 infection in sickle cell disease
Abstract
A 13 year old girl with haemoglobin Sβ+thalassaemia developed simultaneous aplastic crisis and encephalopathy associated with parvovirus B19 (PB19) infection. Brain magnetic resonance imaging findings were consistent with central nervous system (CNS) vasculitis and her symptoms resolved with steroid therapy. Thus, PB19 induced CNS hypersensitivity vasculitis must be considered in the differential diagnosis of encephalopathy.
- parvovirus
- vasculitis
- sickle cell disease
- encephalopathy
- CNS, central nervous system
- CSF, cerebrospinal fluid
- EEG, electroencephalogram
- MRI, magnetic resonance imaging
- PB19, parvovirus B19
- PCR, polymerase chain reaction
- RBC, red blood cell
- SCD, sickle cell disease
- WBC, white blood cell