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Arch Dis Child 87:147-148 doi:10.1136/adc.87.2.147
  • Acute paediatrics

Immunoglobulin levels in methotrexate treated paediatric rheumatology patients

  1. O J Rackham,
  2. J A Sills,
  3. J E Davidson
  1. Department of Rheumatology, Alder Hey Children's Hospital, Eaton Road, Liverpool, UK
  1. Correspondence to:
    Dr O J Rackham, Department of Rheumatology, Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK;
    ojrackham{at}talk21.com
  • Accepted 14 March 2002

Abstract

Retrospective review of serum immunoglobulin levels in 78 methotrexate treated paediatric rheumatology patients showed that IgG, IgA, and IgM levels fell significantly by 26%, 21%, and 17% respectively while on methotrexate. Six patients with systemic disease showed a fall in IgG to below the normal range.

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