Arch Dis Child 86:428-430 doi:10.1136/adc.86.6.428
  • Acute paediatrics

Increasing Plasmodium falciparum malaria in southwest London: a 25 year observational study

  1. J P Williams1,
  2. M Chitre2,
  3. M Sharland2
  1. 1Department of Haematology, St George's Hospital, Blackshaw Road, London SW17 OQT, UK
  2. 2Paediatric Infectious Diseases Unit, St George's Hospital
  1. Correspondence to:
    Dr M Sharland, Paediatric Infectious Diseases Unit, St George's Hospital, Blackshaw Road, London SW17 OQT, UK;
  • Accepted 19 February 2002


Aims: To identify changes in the presenting number and species of imported malaria in children in southwest London.

Methods: A prospective single observer study over 25 years (1975–99) of all cases of paediatric malaria seen at St George's Hospital.

Results: A confirmed diagnosis was made in 249 children (56% boys; 44% girls; median age 8.0 years). Of these, 53% were UK residents and 44% were children travelling to the UK. A significant increase was noted in the number of cases over the 25 years (1975–79: mean 4.8 cases/year; 1990–99: mean 13.7 cases/year). Over the 25 years Plasmodium falciparum was seen in 77%, P vivax in 14%, P ovale in 6%, and P malariae in 3% of cases. P falciparum had increased in frequency (1975–79: P falciparum 50%, P vivax 50%; 1990–99: P falciparum 82%, P vivax 6%), associated with an increase in the proportion of children acquiring their infection in sub-Saharan Africa. Median time between arrival in the UK to the onset of fever was: P falciparum, 5 days; P ovale, 25 days; P malariae, 37 days; and P vivax, 62 days. Median time interval between the onset of fever to commencement of treatment was 4 days. This had not improved over the 25 year period. Only 41% of UK resident children presenting to hospital had taken prophylaxis and the overall number of symptomatic children taking no prophylaxis was increasing.

Conclusion: Imported childhood P falciparum malaria is increasing in southwest London associated with increasing travel from sub-Saharan Africa. Over the 25 year period there has been no improvement in chemoprophylaxis rates or time to diagnosis.