Article Text


Obesity: diagnosis, prevention, and treatment; evidence based answers to common questions
  1. J J Reilly1,
  2. M L Wilson2,
  3. C D Summerbell3,
  4. D C Wilson2
  1. 1University of Glasgow Department of Human Nutrition, Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, UK
  2. 2University of Edinburgh Department of Child Life and Health, Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh EH9 1LF, Scotland, UK
  3. 3University of Teesside, School of Health and Social Care, Middlesborough TS1 3BA, UK
  1. Correspondence to:
    Dr J J Reilly, University of Glasgow Department of Human Nutrition, Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, UK;


Paediatric obesity is now common in the UK, as in other developed countries. A literature search was conducted and evidence based answers to five frequently answered questions sought. Recommendations for diagnosis are given. Although there is no conclusive evidence that the condition is preventable, a number of treatment approaches are promising.

  • obesity
  • randomised controlled trial
  • body mass index
  • meta-analysis
  • systematic review
  • BMI, body mass index
  • RCT, randomised controlled trial

Statistics from

An epidemic of childhood obesity occurred recently across the developed world,1,2 and in many developing countries,3 following an epidemic of adult obesity. There is increasing concern over the likely clinical and public health implications of the epidemic.4,5 However, childhood obesity is difficult to treat and there remains a great deal of uncertainty surrounding its prevalence, diagnosis, prevention, and treatment. The uncertainty and confusion has led to wide variation in clinical practice. The present review aims to provide evidence based answers to five frequently asked questions: How should obesity be diagnosed? What is its prevalence in the UK? Is it preventable? Is it treatable? How should it be managed?


Literature searching

We searched for systematic reviews and meta-analyses using Medline, Embase, Cinahl, Healthstar, the Cochrane Library, and the internet from January 1991 to April 2000. Searching for other study designs used the same databases from January 1981 to June 2000 and was supplemented by manual searching of reference lists of all identified papers, and by manual searching of reference lists of key specialist journals from January 1997 to June 2000. We identified a Cochrane review on interventions for prevention of obesity in children,6 a protocol for a Cochrane review on interventions for treatment of obesity in children,7 and a systematic review which included children but focused largely on adults.8 We compared search results from the present review as a check on the quality of literature searching.

Evidence appraisal

Evidence appraisal used methodology described elsewhere.9 In summary, evidence from the searches was identified using inclusion criteria specific to each question. Two reviewers then appraised each paper independently and agreed on an evidence level and methodological quality rating using the hierarchy of study types published elsewhere.9 In brief, this hierarchy consisted of the following.

  • Evidence level 1, systematic reviews and meta-analyses of randomised controlled trials (RCTs); RCTs

  • Evidence level 2, non-randomised intervention studies, observational/cohort studies

  • Evidence level 3, non-experimental studies, surveys

  • Evidence level 4, expert opinion.

Following published criteria,9 studies were rated as : ++ (all or most methodological criteria met, low risk of bias); + (some criteria not fulfilled or study inadequately described, but low risk of bias); − (few or no criteria fulfilled, high risk of bias). Grades of recommendations (A–D) are based on the strength of the supporting evidence, taking into account its overall level and the considered judgement of the authors.9


Question 1: How should obesity be diagnosed and assessed?

Inclusion criteria

Studies were included: if they assessed the ability of the body mass index (BMI) to identify children with high body fat percentage; if they assessed relations between BMI centile and obesity associated morbidity (for example, cardiovascular risk factors); or if they compared subjective and objective assessment of obesity. Expert committee recommendations were also included .

Use of the BMI

Cross and colleagues10 (table 1) found that (subjective) clinical judgements were inadequate, even when made by experienced observers (evidence level 3). Expert committees have consistently recommended an objective approach (grade D), based on the body mass index centile (grade B) (table 1). Many other authors (in editorials, for example) have also recommended the BMI, but these forms of evidence were not formally appraised. The main advantages of BMI are that it is practical, objective, provides a degree of consistency with adult practice, and is biologically meaningful.

Table 1

Summary of evidence appraised, questions 1–4

The BMI is lower in children/adolescents than in adults, so adult obesity definitions (such as BMI >30.0) should not be applied. The BMI changes during childhood and differs between boys and girls, so age and sex specific reference data (centile cut off points on charts) are necessary to interpret the measurement. For the UK, national reference data for BMI are available.11 These data represent the BMI of British children in 1990 and are widely available in the form of centile charts.11,12

One important consideration with BMI is its ability to successfully classify overweight/obese children and adolescents—that is, its sensitivity and specificity in identification of the fattest children. Nine studies (evidence levels 2+ to 3) addressed this question (table 1) by making direct measurements of body fatness and testing the ability of cut offs applied to the upper end of the BMI distribution to correctly classify the fattest children. These concluded that a BMI cut off in the upper end of the BMI range (for example, above the 85th centile) was specific for obesity (low false positive rate). Expert committees have viewed this as the main consideration when diagnosing obesity as it avoids problems associated with stigmatising children or providing unnecessary treatment.13 However, the magnitude of the false negative problem depends on the cut off which is used. When using BMI >91st centile on the UK 1990 charts for British children, sensitivity is moderately high and specificity high.14 In practice, clinical assessment of obesity in British children using British BMI centile charts will be robust provided that an appropriate cut off (for example, BMI >98th centile) is used. Serial measures of BMI, plotted on the chart, can assess changes over time. In epidemiological use, other cut offs (for example, 85th centile for overweight and 95th centile for obesity) will remain common.2,13 BMI cut offs above the 85th centile are also clinically meaningful. A good deal of evidence shows that children with high BMI are at greatest risk from the morbidity associated with childhood obesity. This includes studies showing associations of BMI with morbidity in childhood,15 with persistence of obesity into adulthood,16 and with presence and clustering of cardiovascular risk factors (evidence level 2++ to 2+).17–19

“International” BMI reference data have been proposed recently for global comparisons of childhood obesity prevalence.20 One British study reported improved screening ability (higher sensitivity; high specificity) when national (UK) reference data were used, compared to use of the international reference data.14 Sensitivity of the definition of obesity using the international reference data differed significantly between the sexes, with low sensitivity in girls and extremely low sensitivity in boys.14 International BMI cut offs for BMI in children have not been related to obesity related morbidity in childhood. They require further testing, with evidence of external validity, before they are adopted. A more extensive discussion of the use of international reference data has been published elsewhere.21

Question 2: What is the prevalence of paediatric obesity in the UK?

Inclusion criteria

Studies were included if they used a definition of obesity based on BMI, in British children. This included nationally representative surveys, regional/local surveys, and cohort studies (table 1).

Prevalence estimates

All three studies identified by the original search indicated a higher prevalence of obesity than expected (evidence level 2+ to 3) (table 1). Only one study was based on a nationally representative sample : obesity prevalence ranged from 11% in 6 year olds to 17% in 15 year olds in England in 1996.1 This evidence shows a notable increase in overweight and obesity prevalence from the early 1990s in the UK. All studies concluded that risk increases with age during childhood and adolescence (evidence level 2+ to 3). One study found that obesity prevalence increased with increasing social deprivation22 (evidence level 3). Obesity prevalence was generally not notably different between boys and girls (evidence level 2+ to 3).

Question 3: Is childhood obesity preventable?

Inclusion criteria

For inclusion, papers had to report a randomised controlled trial (RCT) study design, in a study population drawn from non-clinical samples (that is, subjects from community, school, or nursery), and had to include an objective weight related outcome measure such as BMI or weight change. Studies of both obesity prevention and treatment (question 4) were only included if outcome measures were obtained at least 12 months after the start of the intervention, on the grounds that short term lifestyle change might not be sustainable in the longer term, so short term studies carried a high risk of bias. For questions 3 and 4, RCTs with a negative quality rating were not used as the basis of recommendations and excluded from this review, though reference details and evidence tables are available from the authors.

Evidence appraisal and summary

Three RCTs were identified, but only two studies met our inclusion criteria (Gortmaker et al, 1999; Luepker et al, 1996; table 1). Both studied large samples of schoolchildren, and were of high methodological quality. In both, interventions were complex, with focus on: diet; physical inactivity (targeting reduced TV viewing); physical activity; involvement of schools with changes to curricula; involvement of family. Both interventions were resource intensive, and from the USA. This probably limits the generalisability of their conclusions. Luepker et al (1996) found no significant differences in weight related outcome indices at three year follow up. Gortmaker et al (1999) reported that obesity risk was significantly reduced in girls, but not in boys. In summary, there is some doubt as to whether obesity is preventable in school age children, using currently available intervention strategies (evidence level 1+). Further research is indicated, though more recent evidence, published after the present literature review had been completed, is not promising.23

Question 4: Is childhood obesity treatable?

Inclusion criteria

We included only RCTs , with a study population of children who were defined as obese, and who were followed for at least 12 months post-intervention, for the reasons given above.

Evidence appraisal and summary

We identified 16 studies which met our inclusion criteria. Of these, 12 were from the USA and six were from the same research group. No evidence on drug treatment or residential treatment (“fat camps”) met our criteria. Only three of the 13 trials did not have major methodological flaws, and these were rated as evidence level 1+ (summarised in table 1). Most of the other trials were older studies carried out before the recent development of guidelines for conduct and reporting of RCTs. All were graded as 1− (high risk of bias).

The three high quality studies all delivered complex interventions aimed at achieving long term behavioural change, were resource intensive, and were conducted in specialist clinics (two from the same research group). The studies are therefore difficult to summarise, and there are doubts about their generalisability. In each case diet was combined with lifestyle interventions intended to increase physical activity levels, and families were involved. Increases in physical activity were targeted by a focus on reduction in sedentary behaviour (particularly TV viewing), and/or lifestyle physical activity (for example, walking). In all three studies, treatment significantly reduced indices of overweight/obesity (evidence level 1+). In the absence of clearly generalisable evidence on treatment strategies, further research is indicated. Expert committee recommendations therefore remain useful. These recommend focus on diet and control of sedentary behaviour, with family involvement.13

Box 1: Guidance on management of obese children and adolescents*

Who should be treated?

  • Children defined objectively as obese (BMI >98th centile, UK 1990 reference data)

  • Only children where the child and family appear willing to make the necessary lifestyle changes

(evidence level 4)

What should the aims of treatment be?

  • Resolve comorbidity, if present

  • Aim at behavioural changes, not weight loss: healthier eating; more activity (at least 30 minutes of moderate activity, e.g. brisk walking, most days; less inactivity (i.e., <2 hours TV viewing and computer game use/day)

  • Involve the family in monitoring eating and activity and in making the necessary changes

(evidence level 4)

Who should be referred?

  • Children likely to have serious comorbidity (e.g. sleep apnoea)

  • Children with possible pathological (e.g. endocrine) cause of obesity (e.g. severe obesity in the under 2s; obesity in the presence of short stature)

(evidence level 4)

*From US expert committee recommendations, summarised by Barlow and Dietz.13

Question 5: What do I do with the obese child or adolescent?

This question has three components: Who should be treated? What should treatment aims be? Who should be referred? Recommendations from expert committees/consensus statements were the only evidence which was identifiable to answer these questions (evidence level 4). These are summarised in box 1 and are widely available via the internet.13 Evidence based guidelines from the UK (Scottish Intercollegiate Guidelines Network), based in part on this systematic review, should be available in 2002.


  1. Paediatric obesity is now common in the UK, as in other developed countries.

  2. Obesity should be diagnosed using the BMI centile on the UK 1990 reference charts (Child Growth Foundation, London, UK; printed by Harlow Printing, South Shields, UK), and this should also be used to monitor changes in weight status (grade of recommendation B).

  3. There is no conclusive evidence that childhood obesity is preventable at present, but more research is required. A number of approaches to treatment are promising, notably the control of sedentary behaviour such as TV viewing. These merit further evaluation.


We thank Francesca Chappell for her assistance with literature searching. Work for this review contributed to the Scottish Intercollegiate Guidelines Network guideline on “Obesity in Children and Young People”.


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