Table 1
| Citation | Study group | Study type (level of evidence) | Outcome | Key result | Comments |
|---|---|---|---|---|---|
| Kinsella et al (1999) | 80 preterm babies, <34 wk, randomised to 5 ppm inNO or control | Double blind RCT, single centre (level 1b) | Survival to discharge | RR 1.11 95% CI 0.70–1.8 | Exp group had imroved Pao2 at 60 min; study underpowered |
| The Franco-Belgium Collaborative NO trial Group (1999) | 204 preterm babies, randomised to 10 ppm inNO or control | Open, multicentre, RCT (level 1b) | Ol at 2 h | Median 8.4 (inNO) v 12.4 (control); p=0.005 Greatest in near term infants | Study underpowered; baseline Ol higher in the experimental group |
| Subhedar et al (1997) | 42 preterm babies (<32 wk) randomised to inNO alone; dexamethasone alone; both; neither | Open RCT (level 1b) | Death before discharge and/or CLD | RR 1.05 95% CI 0.84–1.25 for inNO v controls | Neither treatment prevented CLD or death |
| Skimming (1997) | 23 preterms randomised to either 5 or 20ppm inNO | Open RCT (level 1b) | Arterial blood oxygen tension, 15 min after intervention | Equal increases in primary outcome, both groups | Short term physiological study; no control group |
