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Sweat chloride and conductivity 1
  1. VICKY A LEGRYS, Professor, Division of Clinical Laboratory Science
  1. School of Medicine, University of North Carolina at
  2. Chapel Hill, Carolina, USA
  3. vlegrys@med.unc.edu

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Editor,—As a principal author of the sweat testing document published by National Committee for Clinical Laboratory Standards (NCCLS) and consultant to the Cystic Fibrosis Foundation (CFF) (USA), I write to address an inaccuracy in the article by Heeleyet al.1 The authors misrepresent the NCCLS document on the role of conductivity analysis. Nowhere does the NCCLS document refer to the current conductivity methods described in the paper as unreliable; it does restate the widely accepted fact that some older conductivity methods are subject to evaporation error. The NCCLS document goes on to state that the CFF has approved the use of newer conductivity analysers for the screening of cystic fibrosis (CF) at community hospitals, using a decision level of 50 mmol/l.2 This decision level is supported by the data presented in the Heeley article. The data presented in the article concerning equivocal patients also support the US reference interval for sweat chloride …

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