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Arch Dis Child 2001 Volume 84 No 3
Never give up
In 1992, the paediatric network for treatment of AIDS (PENTA) began to recruit children for an RCT of zidovudine (ZDV). As it became clear in adults that combination therapy was superior to ZDV, the paediatric trial was terminated in October 1995.
Vital information has nonetheless become available and appears in this month's ADC (page 230). When the trial was unblinded, parents of children receiving ZDV were offered a second drug and those who had received placebo started on combination therapy. One result is that the trialists are now able to compare the results of children starting “late” or “early” on mono, dual, or triple therapy.
The authors found no evidence of benefit in favour of early ZDV monotherapy. At three years from trial entry, 14% of children had progressed to AIDS or had died. However, progression was significantly lower in 1997–8, probably because more children received dual therapy in later years. This study does not answer the …
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