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Hypertension in Henoch–Schönlein purpura with minimal urinary findings
  1. P M Drummond,
  2. N E Moghal,
  3. M G Coulthard
  1. Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle-upon-Tyne NE1 4LP, UK
  1. Dr MoghalN.E.Moghal{at}ncl.ac.uk

Abstract

THOUGH HYPERTENSION IS A COMMON FEATURE OF HENOCH Schönlein purpura (HSP) acute nephritis, it is seen only rarely and transiently if renal function is normal and abnormal urinary findings are minimal. We report a 3.4 year old girl who had the typical arthritis and rash of HSP, but also had significant hypertension with only minimal urinary findings. Imaging investigations revealed one normal kidney, and one that was almost destroyed from previous reflux nephropathy; her hypertension resolved after unilateral nephrectomy. Other causes of hypertension should be excluded in children with HSP and minimal urinary findings.

  • Henoch–Schönlein purpura
  • nephritis
  • hypertension

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Renal involvement in Henoch–Schönlein purpura (HSP) is common, with an incidence of 20–50%.1 The variation in estimates is probably related to differences in referral patterns to reporting units, in criteria for diagnosing HSP, and in the assessment of renal involvement. Renal involvement is usually minimal, with no more than transient microscopic haematuria, and in these cases blood pressure and renal function are usually normal. Hypertension typically occurs as part of acute HSP nephritis, with impaired renal function, and often oliguric hypervolaemia. However, six children have been reported with minimal or no evidence of renal involvement who had hypertension that resolved on resolution of the HSP.2 3Because of this, it has been recommended that children with HSP, hypertension, and minimal urinary findings should not be investigated for another cause of their hypertension unless it persists after the resolution of their HSP.2 We describe a case where such a child was investigated early, and another cause for her hypertension was found and treated before her HSP had resolved.

Case report

A previously well, normally grown (40th centiles for height and weight) 3.4 year old girl presented with HSP and hypertension with minimal renal involvement. She had had swollen, tender knee, wrist, and metacarpophalangeal joints for five days, a typical palpable purpuric HSP rash on her legs and buttocks for 24 hours, and oedema of her scalp and forehead. Her blood pressure, measured by auscultation and using the largest cuff that would fit on her upper arm was 130/100 mm Hg; the systolic value was confirmed by Doppler ultrasound as ranging between 130 and 150 mm Hg. Fundoscopy was normal. Her plasma creatinine concentrations were normal throughout, varying between 56 and 61 μmol/l, equivalent to a glomerular filtration rate of about 80 ml/min/1.73 m2,4 and her urea and electrolyte concentrations and full blood count were normal. Urine stick testing showed trace to 1+ blood, and 1+ proteinuria; phase contrast microscopy showed only occasional glomerular red blood cells. The early morning urinary protein:creatinine ratio was slightly raised at 67 mg/mmol (normal <20). An autoantibody screen, including rheumatoid factor, C3 and C4 complement, and serum immunoglobulin concentrations were all normal.

Although she remained clinically well with only minimal arthralgia, her hypertension persisted, and she was transferred to our regional paediatric nephrology unit. Her blood pressure was controlled with 0.3 mg/kg nifedipine three times daily and 1 mg/kg atenolol daily. Because her hypertension seemed out of proportion to her degree of HSP nephritis, we investigated her for other causes. Ultrasound examination revealed a normal right kidney and a very small left one with moderate pelvicalyceal dilatation and clubbing, urothelial thickening, and thin parenchyme. The Doppler trace was normal on the right and could not be obtained on the left, indicating a much lower blood flow in that kidney. A dimercaptosuccinic acid scan showed a normal right kidney, and an irregular left kidney which contributed only 9% of the total renal function. She underwent an elective left nephrectomy (fig 1). The histology was diagnostic of reflux nephropathy, and showed no features of dysplasia or HSP; glomerular staining for IgA was negative.

Figure 1

Nephrectomy specimen. (A) Fresh; (B) after fixation and sectioning.

Post-nephrectomy, her systolic blood pressure is normal at 90 mm Hg without any medication, and her urinary albumin:creatinine ratio is normal at 8.0 mg/mmol. However, she has continued to develop new crops of HSP skin lesions.

Discussion

As hypertension has been described as occurring in six children with HSP without renal impairment or urinary abnormalities,2 3 it has been suggested that it is reasonable to defer an extensive evaluation for severe hypertension in this setting until well after the other manifestations of HSP have resolved.2 However, considering that HSP with minimal nephritis is relatively common, the reported frequency of associated hypertension makes this a very rare complication. It is probably less common than the 1 in 1000 incidence of asymptomatic hypertension identified by performing routine blood pressure measurements in ill children.5 The commonest cause of unsuspected hypertension in children is scarring from reflux nephropathy.5 We would therefore argue that delaying investigations for other causes of hypertension in a child with mild HSP nephritis is inappropriate, especially as the initial imaging tests are minimally invasive and HSP may take a very long time to resolve. In the case we describe, the child continued to crop HSP rashes for months after she had received definitive treatment for her hypertension.

References

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