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Outcome of invasive pneumococcal disease: a UK based study
  1. F Shackleya,
  2. K Knoxb,
  3. J Bowen Morrisa,
  4. D Crookb,
  5. D Griffithsa,
  6. R Mayon-Whitec,
  7. R Georged,
  8. L Willockse,
  9. ER Moxon for the Oxford Pneumococcal Surveillance Groupf
  1. aOxford Vaccine Group, University of Oxford, UK, bDepartment of Microbiology, John Radcliffe Hospital, Oxford OX3 9DU, UK, cDepartment of Public Health, Oxford, UK, dCentral Public Health Laboratory, PHLS, Colindale, London, UK, ePHLS Communicable Disease Surveillance Centre (Anglia and Oxford), UK, fUniversity Department of Paediatrics, Oxford, UK
  1. Dr Crook email: dcrook{at}worf.molbiol.ox.ac.uk

Abstract

METHODS The records of 106 children aged less than 5 years with invasive disease caused byStreptococcus pneumoniae were reviewed.

RESULTS The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials.

CONCLUSIONS These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.

  • Streptococcus pneumoniae
  • morbidity
  • mortality
  • outcome

https://doi.org/10.1136/adc.83.3.231

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      Archives of Disease in Childhood 2000; 83 0-0 Published Online First: 01 Sep 2000. doi: 10.1136/adc.83.3.0