Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms
- Tetsushi Yoshikawaa,
- Masaru Ihiraa,
- Kyoko Suzukia,
- Sadao Sugaa,
- Tomoyo Matsubarab,
- Susumu Furukawab,
- Yoshizo Asanoa
- aDepartment of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan, bDepartment of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
- Dr T Yoshikawa, Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Aichi, 4668550, Japan email:
- Accepted 22 March 2000
METHODS A total of 43 children with neurological signs and symptoms were enrolled in the study. All children were suspected of having meningitis, and lumbar punctures were performed. Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction.
RESULTS Most patients had detectable serum antibody to both HHV6 and 7. HHV6 DNA was detected in PBMC of 15 patients and in CSF cell pellet of seven. Corresponding figures for HHV7 were 28 and 6.2/7, and 5/6 with CSF viral DNA also had it in PBMC, respectively. No viral DNA was detected in CSF supernatants. The seven HHV6 CSF viruses were all variant B.
CONCLUSION These data suggest that HHV-7 may invade the CNS.