Article Text
Original article
High IL-18 (interferon-γ inducing factor) concentration in a purine nucleoside phosphorylase deficient patient
Abstract
The plasma concentration of IL-18 (interferon-γ inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.
- purine nucleoside phosphorylase deficiency
- interferon-γ inducing factor
- cytokines