Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis
- aDepartment of Paediatrics, University of Sheffield, Sheffield S10 2TN, UK, bDepartment of Medical Physics and Clinical Engineering, University of Sheffield, cCentre for Human Nutrition, University of Sheffield, dQueen’s Medical Centre, Nottingham NG7 2UH, UK
- Professor C J Taylor, Department of Paediatrics, Sheffield Children’s Hospital, Sheffield S10 2TH, UK.
- Accepted 10 August 1998
OBJECTIVE To investigate gastric emptying and intestinal transit of pelleted pancreatin in relation to food boluses.
Methods—Dual isotope scintigraphy combined with breath hydrogen sampling was used to track the concurrent gastric emptying and intestinal transit of111indium labelled microspheres and a99mtechnetium labelled tin colloid test meal. Twelve pancreatic insufficient cystic fibrosis patients aged 5 to 38 years performed the study.
RESULTS 50% gastric emptying times showed patient to patient variation. The mean discrepancy in 50% gastric emptying times between the two labels was > 67 minutes. Mean small bowel transit time for the food bolus was prolonged at 3.6 minutes. A significant correlation was seen between weight standard deviation score and 50% emptying time for pancreatin (r = +0.73).
Conclusion—Gastric mixing of food and pancreatin may be limited by rapid emptying of microspheres. Patients with high dosage requirements could benefit from changing the pattern of their pancreatin supplementation.