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For the practising paediatrician toddler diarrhoea or chronic non-specific diarrhoea is a frequently encountered disorder. Every paediatrician knows the tableau vivant of extremely worried parents around a sparkling, healthy looking child who appears to be unaware of all the commotion. After a thorough clinical history and a simple physical examination, the diagnosis is often obvious. Both defecation frequency and stool consistency are very different from other children. The stools are foul smelling, watery, and contain mucus with undigested vegetable material. The parents are likely to report a short mouth to anus transit time. Usually, the children have no failure to thrive and they present in a good nutritional state. Abdominal pain may be present in a minority. In the developed, Western countries, toddler diarrhoea is by far the most frequent cause of chronic diarrhoea in children between 1 and 5 years of age. Since the first description in 1966, research on this common condition has mainly concerned its nutritional aspects.1-4
In developed countries toddler diarrhoea is the most frequent cause of chronic diarrhoea in 1–5 year old children
Toddler diarrhoea has a typical dietary and clinical history
Breath hydrogen tests have no place in the diagnostic process
Treatment includes normalisation of feeding patterns according to the “four Fs”: Fat, Fibre, Fluid, and Fruit juices
What is a normal stool?
The defecation pattern of healthy young children is extremely variable in consistency and frequency. Important variations in bowel habits exist between different populations. Normal values for daily frequency and total bowel transit time have been reported for children in industrialised countries.5 For a toddler it may not be abnormal to have more than three soft and occasionally loose stools each day with visible food remnants. In this respect, colonic water absorption and colonic transit are extremely important for faecal consistency. Of all water entering the proximal colon, more than 80% will be retrieved. On a body weight base, young children need to handle more fluid, and they have less effective colonic water absorption and higher faecal water losses as a consequence.6 In general, it is not well recognised that the water content of normally formed stools is as high as 70–75%.7 In a runny, watery stool this will be 90%.7 Therefore, a relatively small increase in water can make all the difference in the parental perception of health and disease. In this respect the important role of the colon is further illustrated in studies on stool form in healthy individuals. Stool form is mainly determined by colonic transit and not by small intestinal passage.8
While most investigators agree that intestinal motility is disturbed in children with toddler diarrhoea at the time of diagnosis, there is no indisputable evidence that it is the primary mechanism of the condition. Research has mainly focused on the small intestine. Normally, duodenal migrating motor complexes result in propulsive activity in the fasting condition and they disappear in response to a meal. In one study these complexes were not interrupted following intraduodenal glucose instalment.9 This may result in a shorter small intestinal transit time, but compared with healthy controls no differences have been observed in total mouth to caecum transit time measured by breath hydrogen tests.10 As most clinicians agree there is a significantly shortened mouth to anus transit time, this puts focus on the motility of the large intestine and a reduced colonic transit time.
It is not clear whether we can include toddler diarrhoea in the larger concept of the irritable bowel syndrome of infancy.11 This concept overlaps with childhood constipation and recurrent abdominal pain.11 12 While these two symptoms are frequently seen together, this seems not to be the case in toddler diarrhoea. One rarely notices a history of constipation in these children, and abdominal pain at presentation is seen in only a small minority. Long time follow up studies are clearly needed for all three conditions.
Nutritional factors are increasingly recognised as playing a key role in both the pathogenesis and treatment of toddler diarrhoea; they may also explain the growing incidence of the condition. In retrospective studies, toddler diarrhoea has been found in children consuming very low fat diets to prevent coronary artery disease,2 on very high fluid intake,3 and with high fluid osmolality.13 In these studies the obvious interventions appeared to be beneficial, but no attention was given to displacement of other components in the diet, and no prospective intervention studies have been reported.
In the past two decades, a number of studies have been performed using breath hydrogen tests to investigate carbohydrate malabsorption. In many Western countries apple juice is extremely popular in young children. Parents perceive apple juice as natural, healthy, nutritious, and relatively inexpensive. In paediatric practice the raw apple diet has a very long reputation in diarrhoeal disorders, probably because of the water holding properties of the apple fibres.14 Hyams and Leichtner were the first to report apple juice as a cause of toddler diarrhoea and complete recovery after its withdrawal.13 These authors also reported positive breath hydrogen tests after consumption of apple juice,13 which made carbohydrate malabsorption the major domain for research in toddler diarrhoea.
All fruit juices contain important, but varying amounts of fructose and glucose. Depending on the fruit, sucrose and sorbitol may also be present. Small intestinal absorption of glucose and sucrose is generally complete, but absorption of fructose15 16 and sorbitol17 is limited and may occasionally provoke gastrointestinal symptoms with abdominal distension, flatulence, abdominal pains, and diarrhoea. At first only sorbitol was incriminated although its concentrations are very low in apple juice.18 19 Later studies suggested that high fructose intake20 or a competition between fructose and sorbitol to use the same intestinal transporter proteins are the main factors involved.21 It is remarkable that eminent nutritional committees have issued recommendations based principally on mere breath hydrogen tests without documentation of accompanying symptoms or signs of carbohydrate intolerance in the stools. The reports focused on fruit juices that have no excess of free fructose and contain no sorbitol—for example, grape and bilberry juice.22 23Manufacturers were keen to include these recommendations for advertising campaigns in a growing market. In the United States more than $200 million is spent each year on bottled baby juice.
In a series of experiments we demonstrated that most healthy young children have positive breath hydrogen tests after fructose ingestion without signs of intolerance. Obviously, these healthy children can break down this malabsorbed carbohydrate efficiently by colonic bacterial fermentation.16 Similarly, even most children with an established diagnosis of toddler diarrhoea had small intestinal fructose malabsorption without diarrhoea.10 Ingestion of different juices including apple, grape or bilberry gave positive breath hydrogen tests, even after removal of fructose and glucose by yeast treatment.24 These results suggest that other components such as polysaccharides and oligosaccharides originating from the fruit or peel are fermented and contribute to the exhaled hydrogen.
In a randomised trial of children with a recent diagnosis of toddler diarrhoea who were free from symptoms after dietary advice, only reintroduction of normal clear apple juice resulted in the recurrence of diarrhoea; these children could tolerate cloudy apple juice.25 Cloudy juice is bottled immediately after pressing, whereas clear apple juice is industrially prepared by means of enzymatic treatment of the apple pulp to obtain a higher yield and an attractive clear product. The products therefore differ in the amount of dietary fibre and the amounts of indigestible monosaccharides and oligosaccharides. However, as the amounts of fructose and sorbitol were identical in both products, these studies further disclaim malabsorption of those carbohydrates as principal factors in toddler diarrhoea.
It is only recently that we have a better understanding of the interactions between fermentation and normal colonic function. The general view on the role of the colon for carbohydrates that are not absorbed in the small intestine is changing. Previously seen as an organ that might “salvage” these nutrients and prevent osmotic diarrhoea, the colon is now considered more as a complex metabolic factory where a constant flow of mainly complex carbohydrates is a prerequisite for proper function. In the proximal colon these carbohydrates are fermented by colonic bacterial flora into short chain fatty acids (SCFAs)—the main nutrients for colonocytes and important anions for colonic sodium and water absorption. SCFAs are believed to have feedback regulations on gastric emptying and small intestinal transit.26 In addition, SCFAs have a number of properties that may be important in maintaining normal bowel structure and function and preventing colon based diarrhoea.27 Whether these mechanisms are disturbed in the child with toddler diarrhoea remains unclear, but it provides an attractive new field of investigation.
“Newtrition” versus nutrition
In developed countries, the diet of children, especially of infants and toddlers, has changed dramatically over the past years. Paediatricians and other physicians are increasingly consulted not only for toddler diarrhoea but also for other health problems related to these changes. Ready-made products increasingly replace food prepared fully by parents. Here, new nutritional habits originate that go together with an increase in affluence. Drinking plain water is out of vogue.28 It has largely been replaced by fruit juice and squash.28 Drinks are consumed on a more or less constant basis, often by a drinking bottle. They provide a high number of calories and may diminish the appetite. Reports from the United States indicate that these mainly carbohydrate containing fluids contribute to unbalanced nutrition.29 In clinical practice we encounter young children having excess juice consumption as a contributing factor in non-organic failure to thrive.29 30 In a cross sectional sample of healthy young children, excess fruit juice consumption was associated with short stature and obesity.31
Frequently, drinking fruit juice results in a high fluid intake with displacement of fat and fibre from the diet. More parents seem to be concerned with obesity and intend to offer low calorie drinks, not being aware of the fact that, because of its high carbohydrate content, fruit juice equals the caloric content of many popular dairy products. In the modern diet the intake of grain products, fruit, and vegetables is declining. Large numbers of children are not meeting minimum fibre intake recommendations.32 Consumption of most ready-made meals and a high juice intake further contributes to deficient fibre ingestion.
After a thorough clinical history and a simple physical examination, the diagnosis is often obvious. The main message to the parents is reassurance on underlying serious gastrointestinal disorders and normalisation of the diet. Kneepkens and Hoekstra proposed a normalisation of the child’s feeding pattern according to the “four Fs”: Fat, Fibre, Fluid, and Fruit juices.4 As it seems that these children represent the end of a spectrum of normality, the dietary treatment will often be close to the borders of normal nutritional recommendations. Fat intake should be increased to at least 35%, even 40%, of total energy intake. Restoration of a pattern with well defined meals and snacks provides the opportunity for significant increases of fibre intake. Fruit juices, in particular clear apple juice, and other squashes should be limited to restore appetite at meal times. Drinks between meals are acceptable, but overconsumption should be discouraged. In almost all patients the efficacy of these dietary measures is such that it may even serve as a confirmation of the diagnosis.11 25 Some authors have used aspirin,33 loperamide33 or mebeverine11 for cases refractory to dietary measures. Their effects last as long as they are given. As a consequence, medication seems to be unwarranted for a condition that does not hamper the child to thrive.
The problems in children with toddler diarrhoea often start following acute gastroenteritis. Instructed to prevent dehydration parents persistently offer clear liquid and therefore start a vicious cycle of dietary restrictions and continuing diarrhoea. A greater awareness of modern treatment of acute gastroenteritis with oral rehydration solutions to combat dehydration followed by rapid resumption of normal feeding 3–4 hours after rehydration will prevent toddler diarrhoea starting in many potential cases.34
Toddler health will benefit from widely accepted nutritional recommendations. A consensus on dietary fat and fibre will pave the road to practical recommendations. Not in the least these will have to include lifestyle related aspects.
It is evident that toddler diarrhoea is worrisome for many parents. It is a condition related to modern affluent societies where new nutritional practices have emerged. Related to these changes clinicians see children with toddler diarrhoea, nutritional deficiencies, and even manifest failure to thrive with stunting. The long term health effects remain uncertain. For paediatric medicine, fine tuned to the optimal nutrition for the young infant, the challenging field for nutritional research with toddlers remains largely unexplored.
Finally, what will be the thoughts of worried parents of a child with longstanding diarrhoea? Following an explanation and dietary advice, they may leave with some scepticism. The advice with regards to a normal healthy diet seems to be too simple and does not fit adequately into the expectations concerning modern specialist care. However, within days they will notice that this simple advice, if followed, is very effective.
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