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Hereditary CD4+ T lymphocytopenia
  1. Serem Freiera,
  2. Eitan Kerema,
  3. Zvi Dranitzkib,
  4. Michael Schlesingerc,
  5. Ruth Rabinowitzc,
  6. Chaim Brautbard,
  7. Mahmoud Ashkirate,
  8. Yaakov Naparstekb
  1. aDepartment of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel, bDepartment of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel, cHubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel, dTissue Typing Laboratory, Hadasssah University Hospital, Jerusalem, Israel, eWorker’s Sick Fund Clinic, Sheikh Jarrah, Jerusalem, Israel
  1. Professor Serem Freier, Laboratory of Mucosal Immunology, Shaare Zedek Medical Center, POB 3235, Jerusalem, Israel.

Abstract

Two siblings suffering from mental retardation, progressive bronchiectasis, extensive warts, and persistent hepatitis B are described. The propositus also had an unusual physiognomy and non-specific colitis. Both patients had a marked decrease in the population of CD4+ helper T cells.

  • CD4+ lymphocytopenia
  • immunodeficiency
  • common variable immunodeficiency

https://doi.org/10.1136/adc.78.4.371

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