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Letters to the editor
Primary manifestation of Henoch-Schönlein purpura during immunosuppressive treatment
  1. MATTHIAS SCHWAB,
  2. ROLF BEHRENS,
  3. HANS RUDER,
  4. KLAUS KORN

    *

  1. University Hospital for Children and Juveniles and Institute of Clinical and Molecular Virology*
  2. University Erlangen-Nuernberg
  3. D-91054 Erlangen, Germany
  4. (Correspondence to: Dr Matthias Schwab
  5. Dr Margarete Fischer-Bosch Institut fuer Klinische Pharmakologie
  6. Auerbachstrasse 112 D-70376
  7. Stuttgart, Germany)

    https://doi.org/10.1136/adc.77.2.183d

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      Editor,—Although numerous investigations suggest an immunological process involving a disturbance of the regulatory mechanism for IgA synthesis,1 the aetiology of Henoch-Schönlein purpura are still unresolved.

      We report a 4 year old boy who received a liver transplant at the age of 3 years after developing a fulminant liver failure due to intoxication with α-amanitin. After transplantation, immunosuppressive treatment with cyclosporin (Neoral, Sandoz) and prednisone was carried out. During later care the cyclosporin trough serum concentrations always exceeded 100 ng/ml, while simultaneously the dose of corticosteroids was reduced to 1 mg/day. …

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