Editor,—In 1985 one of us (ROR) published a case of unusual self resolving leukodystrophy.1 We now describe a second case. As with the first, neuroimaging was prompted by a large head size. At 14 months, she had an occipitofrontal circumference of 53.5 cm some 4 SDs above the mean. Her father’s head circumference was similarly increased being 63 cm. His …