Severe combined immunodeficiency with abnormalities in expression of the common leucocyte antigen, CD45
- Department of Immunology and Infectious Diseases, Great Ormond Street Hospital NHS Trust, Great Ormond Street, London WC1N 3JH
- Dr Cale.
- Accepted 16 September 1996
Abstract
Children presenting with disseminated viral infections should be carefully investigated because they almost invariably have an underlying immunodeficiency. A child is reported who had disseminated cyto-megalovirus and a novel form of severe co-mbined immunodeficiency with abnormal expression of the common leucocyte antigen, CD45.
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Disseminated cytomegalovirus infection is usually associated with immunodeficiency
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The absolute lymphocyte count is low in the majority of cell mediated immunodeficiencies
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Active cytomegalovirus infection is a poor prognostic feature in bone marrow transplantation
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Molecular characterisation of novel immunodeficiencies may give insights into the normal functioning of the immune system
