Severe combined immunodeficiency with abnormalities in expression of the common leucocyte antigen, CD45
- Department of Immunology and Infectious Diseases, Great Ormond Street Hospital NHS Trust, Great Ormond Street, London WC1N 3JH
- Dr Cale.
- Accepted 16 September 1996
Children presenting with disseminated viral infections should be carefully investigated because they almost invariably have an underlying immunodeficiency. A child is reported who had disseminated cyto-megalovirus and a novel form of severe co-mbined immunodeficiency with abnormal expression of the common leucocyte antigen, CD45.
Disseminated cytomegalovirus infection is usually associated with immunodeficiency
The absolute lymphocyte count is low in the majority of cell mediated immunodeficiencies
Active cytomegalovirus infection is a poor prognostic feature in bone marrow transplantation
Molecular characterisation of novel immunodeficiencies may give insights into the normal functioning of the immune system