Arch Dis Child 67:944-947 doi:10.1136/adc.67.7.944
  • Research Article

Transient hypothyroxinaemia associated with developmental delay in very preterm infants.

  1. W J Meijer,
  2. S P Verloove-Vanhorick,
  3. R Brand,
  4. J L van den Brande
  1. TNO Institute of Preventive Health Care, Leiden, The Netherlands.


      In 563 surviving very preterm (less than 32 weeks gestational age) and/or very low birthweight (less than 1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative score on the three milestones of development. These findings do not support the view that transient hypothyroxinaemia in preterm infants is harmless.