Continuous rectal temperature recordings were made from 32 babies the night after their first diphtheria, pertussis, and tetanus immunisation and compared with recordings made before immunisation. Tog values of clothes and wrapping and room temperatures were also recorded. We found that immunisation the day before disturbs the normal night time rhythm of deep body temperature. The rectal temperature of immunised babies was significantly higher than non-immunised babies from two hours into the night. We also found that there were considerable individual variations in the extent of disturbance of temperature rhythm. They were not correlated with thermal environment. There is no reason to suppose that these mild physiological responses to immunisation are in any way harmful.
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