Article Text


Acute effects of instillation of surfactant in severe respiratory distress syndrome.
  1. H L Halliday,
  2. F B McCord,
  3. B G McClure,
  4. M M Reid
  1. Department of Child Health, Queen's University of Belfast.


    Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ventilator settings and increases in the extent of chest wall movements measured by a cardiorespiratory monitor suggested that the improvement after surfactant had been given was a result of alveolar stabilisation and increased pulmonary compliance. Further simultaneous studies of pulmonary blood flow and pulmonary compliance are needed to confirm these findings.

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