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Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.
  1. J A Eyre,
  2. D Gardner-Medwin,
  3. G P Summerfield
  1. Department of Child Health, Medical School, University of Newcastle upon Tyne.

    Abstract

    Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nervous system prophylaxis.

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