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Premature thelarche: a follow up study of 40 girls. Natural history and endocrine findings.
  1. A M Pasquino,
  2. L Tebaldi,
  3. L Cioschi,
  4. C Cives,
  5. G Finocchi,
  6. M Maciocci,
  7. G Mancuso,
  8. B Boscherini

    Abstract

    Follow up of 40 girls with premature thelarche showed that where this disorder occurred before age 2 years it usually regressed completely, thus representing a transient and isolated phenomenon. Premature thelarche after age 2 years persisted more frequently, however, and represented the first sign of sexual development, generally leading to simple early puberty.

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