Article Text

PDF

Early rise in the "pitted" red cell count as a guide to susceptibility to infection in childhood sickle cell anaemia.
  1. D W Rogers,
  2. B E Serjeant,
  3. G R Serjeant

    Abstract

    "Pitted" red cell counts (pit counts) were performed serially during a period of 18 months in 130 Jamaican children with homozygous sickle cell (SS) disease aged 0-4 years. Raised pit counts, defined as 10% or more "pitted" red cells, were present in 23% of the children at age 12 months, in 42% at age 24 months, and in 52% at age 36 months. Radioactive colloid spleen scans showed no splenic uptake in 11 children with palpable spleens and raised pit counts. Eight episodes of severe bacterial infection occurred in 7 children, all of whom had raised pit counts before (n = 6) or at the time of infection (n = 1). Of the 52 children with pit counts followed from age 12 months or younger, all 4 who developed severe infections had raised pit counts at or before age 12 months. Pit counts are a guide to susceptibility to severe infections in SS children. Children whose pit counts rise before age 12 months are at greater risk of subsequent infection; this may be related to loss of splenic function before first encounter with the infecting organism.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.