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Pituitary cretinism in two sisters.
  1. H Kohno,
  2. N Watanabe,
  3. M Ootsuka,
  4. M Kajiwara,
  5. N Gohya

    Abstract

    Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after administration of thyrotropin-releasing hormone. We conclude that cretinism in these 2 sisters was due to TSH deficiency. This is the second report of 'familial' pituitary cretinism (TSH-deficient congenital hypothyroidism).

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