Article Text

PDF

C-trisomy in a case of neonatal leukaemia.
  1. M F Whitfield,
  2. D G Barr,
  3. M L O'Riordan

    Abstract

    A case of neonatal leukaemia of acute myeloid cell type was diagnosed at age 8 weeks and the patient died shortly afterwards with evidence of disseminated intravascular coagulation. An aneuploid malignant cell line 47, XY+C was found, in addition to the infant's normal constitutional karyotype. Eight other cases of congenital or neonatal leukaemia with aneuploid malignant cell lines are reviewed. C-trisomy is a commonly acquired chromosomal abnormality in a wide range of malignant and premalignant haematological disorders, and its possible significance in relation to leukaemogenesis in this case is discussed.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.