Article Text

PDF

Cyclophosphamide therapy in prepubertal rats and subsequent reproductive performance
  1. C. L. Berry

    Abstract

    In an experimental system using rats, prepubertal treatment with cyclophosphamide was associated with slightly reduced fertility of the adult female. No malformations were noted in the offspring, and there was no change in the size of the rat pups produced. Reduction in litter size was apparent by day 11 of gestation, suggesting that losses before or around implantation were the most likely cause of the reduction in litter size.

    The relevance of these results to cytotoxic drug therapy in the nephrotic syndrome in childhood is considered.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.