A comparison of the intestinal absorption of water miscible and fat soluble preparations of α-tocopheryl acetate in children with cystic fibrosis showed the water miscible preparation to be more efficiently absorbed. In the absence of liver disease, a daily dose of 1 mg/kg body weight of a water miscible preparation can be expected to correct any pre-existing vitamin E deficiency within 2 months of starting treatment, and is adequate for subsequent maintenance.
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