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Effect of Alterations in Mechanical Ventilator Settings on Pulmonary Gas Exchange in Hyaline Membrane Disease
  1. E. O. R. Reynolds

    Abstract

    The effect of altering peak airway pressure, respiratory frequency, and inspiration: expiration ratio on arterial blood gas tensions, blood pressure, and calculated right-to-left shunt was investigated in 6 infants undergoing mechanical ventilation for hyaline membrane disease with a Bennet ventilator. The use of a very long inspiratory phase resulted in a large increase in Pao2 and fall in right-to-left shunt without affecting mean arterial blood pressure.

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