The effect of 3α,20β-pregnanediol and other steroids on bilirubin conjugation was examined using liver tissue from human and four other species. Neither 3α,20β-pregnanediol nor 3α,20β-pregnanediol inhibited conjugation by human liver slices or by solubilized human liver microsomes. 3α,20β-pregnanediol is unlikely to be the inhibitor causing breast milk jaundice.
Oestriol inhibited conjugation by human liver slices. A comparison of species indicated that the response of the human liver slice system to steroids resembles that of the rabbit and guinea-pig rather than the rat or mouse.
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