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In November 2017’s issue of Archives there were a number of articles addressing the important area of the clinical approach to children with developmental delay. The investigations performed are very variable across the UK and this is a key area where the clinical and cost-effectiveness of every laboratory investigation needs to be further evaluated. Hart et al 1 suggest a very limited metabolic screen for children with developmental delay without additional features, whereas Mithyantha et al 2 suggest more extensive metabolic screening.
We cannot agree with the very limited metabolic screen proposed by Hart et al 1 for children with developmental delay without additional features. We agree …
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