The disruption of brain ontogeny phases leads to major early malformations, such as forebrain, anencephaly. Cephalic malformations are most commonly hydrocephalus and microcephaly.
The authors have analysed data collected from the medical observation sheets of Paediatrics Clinic II, Craiova, for patients hospitalised between 2007–2015, with diagnoses of CNS malformations.
Results there were 87 patients with brain malformations in the study. The types of defects noted: microcephaly: 46; hydrocephalus: 21; pellucida/arachnoid septum cyst : 3 and 3; cave of septum pellucidum: 1; right cerebral hemisphere atrophy-1; agenesis of the corpus callosum-1, Dandy Walker syndrome-1; periventricular cysts-1; mirror movement disorder(splitting cerebral) −1, holoprosencephaly-1. The outcome was lethal to 12 children in the reviewed period, others were transferred, but 7 patients with myelomeningocele and hydrocephalus were operated successfully.
Surgical treatments improved survival rate in case of congenital cranial defects, as demonstrated by this study.
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