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OC-82 The role of cerebral and splanhnic saturation for the outcome of newborns with necrotizing enterocolitis
  1. Andreea Avasiloaiei,
  2. Elena Hanganu,
  3. Mihaela Moscalu,
  4. Liliana Pop,
  5. Maria Stamatin
  1. Department of Mother and Child Care, « Grigore T.Popa » University of Medicine and Pharmacy, Iasi, Romania Department of Surgery, « Grigore T.Popa » University of Medicine and Pharmacy, Iasi, Romania Department of Interdisciplinary Sciences, « Grigore T.Popa » University of Medicine and Pharmacy, Iasi, Romania Cuza-Voda Neonatal Intensive Care Unit, Iasi, Romania

Abstract

Near-infrared spectroscopy (NIRS) to measure somatic and cerebral saturations is increasingly used in Neonatal Intensive Care Units for the monitoring of various conditions, including congenital heart defects, renal disease or intestinal conditions. Splanchnic saturation is used for predicting impending necrotizing enterocolitis (NEC), but its’ fluctuations make it rather difficult to analyse. The Somatic-Cerebral Oxygenation Ratio (SCOR) has been developed recently to monitor healthy term and preterm infants as well as sick children as a more stable measurement of overall oxygenation.

Material and methods We conducted a prospective study over three years (2014–2016) on 61 newborns, 38 preterm infants with clinical signs of NEC and 23 infants used as control group. We simultaneously measured cerebral and splanchnic saturations through NIRS. We calculated the Receiver Operating Characteristics Curve for all the parameters, in order to assess their value as predictive factors for NEC.

Results The preterm infants who developed NEC had a mean gestational age of 31 weeks (IQR=27–33 weeks) and a mean birth weight of 1311 grams (IQR 900–1850). Splanchnic saturations had values between 15% and 69% in infants with NEC and 54%–88% in infants without NEC, with statistically significant differences between the two groups (p<<<0.01). Cerebral saturations had values between 15% and 85% in infants with NEC and 62%–95% in infants without NEC, also with significant differences (p<<<0.01). SCOR had values of 0.25–1.03 when NEC was diagnosed and 0.61–1.16 when NEC was absent (p<<<0.01). The area under the curve (AUC) is 0.914 for splanchnic saturation, 0.840 for cerebral saturation and 0.747 for SCOR (p<<<0.01).

Conclusions SCOR is significantly different in infants with and without NEC. Both its’ sensitivity and specificity are lower than those of splanchnic saturation, but SCOR can be preferred in the clinical settings due to its’ smaller variations.

  • somatic-cerebral saturation ratio
  • necrotizing enterocolitis
  • predictive factor

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