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P379 Ace inhibitors eforts in chidlren with ckd 1 stage
  1. Olga Komarova,
  2. Alexey Tsygin,
  3. Ivan Smirnov,
  4. Alla Kucherenko
  1. National Scientific centre of children’s health

Abstract

Background ACE inhibitors (iACE) antifibrotic mechanisms for CKD progression is still investigated among them their influence for intercellular interaction and apoptosis regulation

patients and methods TGB-1, metalloproteinase-9 ( MMP-9), sFas-receptor, fibronectin serum levels were measured in 24 normotensive children 9–12 years with non-immune CKD 1 stage with proteinuria 0,4±0,04 g/days divided in 2 groups- 11 with regular fozinopril 0,2±0,03 (0,1–0,3) mg/kg treatment and 13 without ACE inhibitors.

Results Pro- sclerotic agents TGB-1, fibronectin, sFas-receptor were significantly low in children with iACE therapy, and the level of MMP-9 proteolytic activity was higher according to patients without iACE treatment.

Conclusion This analysis has allowed to describe one of the main aspects of antiproteinuric and, respectively, antifibrotic effort for iACE: reduction of activity of pro-sclerotic substances and strengthening of proteolytic activity in an extracellular matrix.

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