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P285 The relationship between pregnancy and birth related factors and autism spectrum disorders
  1. Iuliana Dobrescu1,
  2. Ilinca Mihailescu2,
  3. Gianina Anghel3,
  4. Mihaela Stancu4,
  5. Alexandra Buica5,
  6. Florina Rad6
  1. 1Primary doctor in Neuropsychiatry, Child and Adolescent Psychiatry Department, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, Bucharest, Professor, Child and Adolescent Psychiatry Department, University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Romania, iulianadobrescu@yahoo.com
  2. 2Specialist doctor in Child and Adolescent Psychiatry, Child and Adolescent Psychiatry Department, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, Bucharest, PhD student, University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Romania
  3. 3Specialist doctor in Child and Adolescent Psychiatry, Assistant Professor, University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Romania
  4. 4Resident in Child and Adolescent Psychiatry, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, Bucharest
  5. 5Specialist doctor in Child and Adolescent Psychiatry, PhD student, University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Romania
  6. 6Primary doctor in Child and Adolescent Psychiatry, Child and Adolescent Psychiatry Department, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, Bucharest Child and Adolescent Psychiatry Department, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, Bucharest, Lecturer, University of Medicine and Pharmacy ‘Carol Davila’ Bucharest, Romania

Abstract

Background and aims Autism spectrum disorders (ASD) are a group of pervasive developmental disorders characterised by impaired communication, impaired social interaction, restricted and repetitive interests and behaviours. Previous studies showed that a focus on prenatal, perinatal, and neonatal events may identify factors linked to autism spectrum disorder.

This presentation aims to emphasise the information collected from a cross sectional study conducted in the Department of Child and Adolescent Psychiatry, ‘Prof. Dr. Al. Obregia’ Psychiatry Hospital, in Bucharest. The main objective of this study was to identify potential association between certain perinatal risk factors and the occurrence of ASD.

Methods In the study were included 52 subjects with ASD and 52 typically developing children (matched for age and gender).

To their caregivers was applied a structured parent – informant questionnaire, that aimed to assess the following factors: familial antecedents, exposure to environmental toxins during pregnancy, using medications in pregnancy, intrauterine infections, risk of miscarriage, fetal complications during labour and delivery, birth weight, APGAR score, mental and motor development during infancy, personal pathological antecedents.

Results After statistical analysis, there was found significant association between the presence of ASD and: taking medications during pregnancy, fetal complications during labour and delivery, pregnancy with increased risk of miscarriage, low birth weight and APGAR score, history of psychiatric conditions in family and personal pathological antecedents, abnormal mental development during infancy.

There was no relationship between ASD and the exposure to environmental toxins in pregnancy, intrauterine infections, abnormal motor development during infancy and parental age at childbirth.

Conclusions Most of the findings are consistent with those of other prior studies. These data suggest that the etiologically relevant period may be in utero because the pathogenesis may begin during the prenatal period.

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