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P267 Newborn infected with hiv, virus c, virus b, cmv – case presentation
  1. MARDARESCU MARIANA,
  2. UNGURIANU RODICA,
  3. POPESCU ANCA
  1. NATIONAL INSTITUTE OF INFECTIOUS DISEASE ‘PROF. DR. MATEI BALS’, BUCURESTI

Abstract

BACKGROUND Mother to baby transmission is well documented for hepatitis B virus (HBV) and the human immunodeficiency virus (HIV). Although are case reports of vertical transmission of hepatitis C virus (HCV), it remains uncertain to what extent infected mother transmit this virus to their infants. Hepatitis C virus (HCV) infection is characterised by persistent viraemia and the virus is a major cause of liver disease including cirrhosis and hepatocellular carcinoma. There are also major clinical, virologic, immunologic and also the effect of CMV on the progression of HIV disease at a newborn.

Methods This work presents the case of a premature newborn (33 weeks), extracted by caesarean section, partially investigated pregnancy, W=2360 g, Apgar score 8. The newborn was initially considered exposed HIV but quickly after tests he was diagnosed as symptomatic HIV – C1.

At short time after birth present general condition modified and after blood tests he was diagnosed also with hepatitis B, hepatitis C and CMV virus.

Results AND ConclutionS Was started therapy with lamivudine and zidovudine. What you will do in this case? How you will manage such a difficult case? What you will choose as a third antiretroviral therapy?

HCV is vertically transmitted from mother to infant and the risk of transmission is correlated with titer of HCV RNA at the mother.

CMV co-infection was correlated with rapid progression of HIV disease and with devastating early central nervous system disease.

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