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P257 The analysis of the immunisation schedule in patients with juvenile idiopathic arthritis
  1. Leyla S Namazova-Baranova,
  2. Marina V Fedoseenko,
  3. Saniya I Valieva,
  4. Ekaterina I Alekseeva,
  5. Anna G Gaivoronskaya,
  6. Daria A Novikova,
  7. Natalia E Tkachenko,
  8. Tatiana A Kaljuzhnaya,
  9. Firuza Ch Shakhtakhtinskaya,
  10. Marika I Broeva,
  11. Daria S Chemakina
  1. Federal State Autonomous Institution ‘National Scientific and Practical Centre of children’s Health’ of the Ministry of Health of the Russian Federation, Moscow

Abstract

Background Juvenile Idiopathic Arthritis (JIA) is the most common rheumatologic disease in children, which development is influenced by the occurred infection along with the genetic factors. Vaccination of the patients with JIA should be considered an important measure to prevent comorbid infections, which influences the progression and outcomes of the rheumatologic disease.

Objective to study vaccination status in patients with JIA.

Materials and methods A cross-sectional retrospective study of 44 children aged 1,5–13 years with the confirmed JIA was conducted. Anamnesis was obtained via parents’ interviews. Personal medical documentation was analysed.

Results It was observed that only 27% of patients with JIA were vaccinated according to the National Immunisation Program (NIP). Every 4th child (23% patients) was not vaccinated against main vaccine preventable diseases. Moreover, only 5% of children had vaccination against flu. One unvaccinated child had a manifestation of JIA soon after having measles infection. Before the onset of the autoimmune disease, 56% of children did not follow the NIP and 44% had their vaccination postponed due to the existing rheumatologic condition. Only non-significant number of mothers (9%) connect the manifestation of rheumatologic disease with the conducted vaccination. Moreover, the anamnestic data about the post-vaccination reactions were collected: 88% of children, vaccinated with live vaccines against measles, rubella, epidemic parotitis and polio had no post-vaccination reactions, whereas in 12% of cases a moderate short-lasting joint swelling was observed. Every second vaccination (48%) with an inactivated vaccine caused local or general mild and moderate adverse reactions.

Conclusion The prevalent number of patients with JIA needs correction of the vaccination schedule.

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