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P242 Helicobacter pylori infection and specific immunoglobulin e antibodies to food allergens in symptomatic children admitted in a digestive endoscopy unit
  1. Victoria Hurduc,
  2. Luiza Bordei,
  3. Eugenia Buzoianu,
  4. Doina Anca Plesca
  1. Victor Gomoiu Clinical Children’s Hospital, ‘Carol Davila’ University of Medicine and Pharmacy

Abstract

introduction: Helicobacter pylori is one of the most widespread bacterial infections worldwide, therefore nowadays its prevalence was decreasing, mostly in developed countries. There are some studies which support that H pylori could favour the development of food allergy.

Objectives To assess the relationship between H pylori infection and specific immunoglobulin E (Ig E) antibodies to food allergens in symptomatic children.

Methods We conducted a prospective study of 394 symptomatic children (249 girls, age range 6 months-18 years), mostly with uninvestigated dyspepsia requiring an endoscopic evaluation in our unit, from January to November 2016. All patients were evaluated for H pylori infection by at least two standard invasive tests and for specific immunoglobulin E antibodies to major food allergens ( R-biopharm, Germany). The nutritional status of patients was assessed in all cases by the new World Health Organisation (WHO, 2007) growth charts. EPI-INFO version 7 was used for statistical analysis.

Results Active H pylori infection was documented in 246 (62,3%) cases. The allergic sensitisation to at least one of the food allergens was identified in 134 of 394 patients (34%). The majority of Ig E positive children (109 of 134 cases; 81,3%) were positive for cow’s milk followed by egg (17,9%), wheat (7,46%), peanut (4,5%), soybean (3,73%). The allergic sensitisation to food allergens was associated with abnormal levels of specific Ig E antibodies to common inhalatory allergens in 55 of 134 cases (41,04%). Regarding the association of H pylori infection with an elevated serum Ig E level to at least one of the food allergens tested, there was no significant correlation (p=0,14). 77 of 134 (31,30%) patients positive for food specific Ig E antibodies were H pylori infected and 57 of them (38,55%) were H pylori negative (Fisher exact test=0,08). The assessment of the patients nutritional profile in relationship with H pylori infection and food allergy not revealed a statistically significant effect on the two ends of the poor nutritional status (undernutrition and overnutrition).

Conclusions This endoscopic series revealed that the recent decline of H pylori infection observed in developed countries is not evident in our symptomatic children. There was no association between H pylori infection and Ig E mediated food allergy. Undernutrition and overnutrition were not associated with the H pylori infection and food allergy in our patients.

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