Article Text

G292(P) Diagnostic accuracy of the nexus II head injury clinical decision rule in children. A predict prospective cohort study
  1. FE Babl1,2,3,4,
  2. M Borland1,5,6,
  3. N Phillips1,7,
  4. A Kochar1,8,
  5. S Dalton1,9,
  6. JA Cheek1,2,3,10,
  7. Y Gilhotra1,7,
  8. J Furyk1,11,
  9. J Neutze1,12,
  10. S Bressan1,3,
  11. S Donath3,4,
  12. C Molesworth3,
  13. L Crowe3,
  14. S Hearps3,
  15. M Arpone3,
  16. E Oakley1,2,3,4,
  17. SR Dalziel1,13,14,
  18. MD Lyttle1,3,15,16
  1. Paediatric Research in Emergency Departments International Collaborative, Australia/New Zealand
  2. Emergency Department, Royal Children’s Hospital, Melbourne, Australia
  3. Murdoch Children’s Research Institute, Melbourne, Australia
  4. Department of Paediatrics, University of Melbourne, Melbourne, Australia
  5. Emergency Department, Princess Margaret Hospital for Children, Perth, Australia
  6. Schools of Paediatrics and Child Health and Primary, Aboriginal and Rural H, University of Western Australia, Perth, Australia
  7. Emergency Department, Lady Cilento Children’s Hospital, Brisbane, Australia
  8. Emergency Department, Women’s and Children’s Hospital, Adelaide, Australia
  9. Emergency Department, The Children’s Hospital at Westmead, Sydney, Australia
  10. Emergency Department, Monash Medical Centre, Melbourne, Australia
  11. Emergency Department, The Townsville Hospital, Townsville, Australia
  12. Emergency Department, Kidzfirst Middlemore Hospital, Auckland, New Zealand
  13. Emergency Department, Starship Children’s Health, Auckland, New Zealand
  14. Liggins Institute, University of Auckland, Auckland, New Zealand
  15. Emergency Department, Bristol Royal Hospital for Children, Bristol, UK
  16. Faculty of Health and Applied Science, University of the West of England, Bristol, UK


Aims Clinical decision rules (CDRs) can be applied in Emergency Departments (EDs) to optimise the use of computed tomography (CT) in children with head trauma. The National Emergency X- Radiography Utilisation Study II (NEXUS II) CDR, as amended for children, has not been externally validated in a large paediatric cohort.

The objective of this study was to conduct a multicentre external validation of the NEXUS II CDR in children.

Methods We performed a prospective observational study of patients<18 years presenting with head trauma of any severity to 10 Australian/New Zealand EDs. In a planned secondary analysis we assessed the performance of the NEXUS II CDR for its diagnostic accuracy (with 95% confidence intervals (CI)) in predicting clinically important intracranial injury (ICI) as identified in CT scans performed in ED.

Results Of 20 137 total patients, we excluded 28 with suspected penetrating injury. Median age was 4.2 years. CTs were obtained in ED for 1962 (9.8%), of whom 377 (19.2%) had a clinically important ICI as defined by NEXUS II. 74 (19.6%) of these patients underwent neurosurgery. Sensitivity for clinically important ICI based on the NEXUS II CDR was 373/377 (98.9%; 97.3%–99.7%) and specificity 156/1585 (9.8%; 8.4%–11.4%). Positive and negative predictive values were respectively 373/ 1802 (20.7%; 18.8%–22.6%) and 156/160 (97.5%; 93.7%–99.3%). Of the 18 147 children who did not have a CT scan 49.5% had at least one NEXUS II risk criterion.

Conclusions NEXUS II had very high sensitivity when analysed with a focus on head injured patients who have had a CT performed, similar to the derivation study. With half of the unimaged patients positive for NEXUS II risk criteria the use of this CDR has the potential to increase the number of CTs.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.